SR-121463A  185913-79-5

价格:8800元/公斤 含量:99% 包装:25公斤

CAS;185913-79-5

分子式：C17H22ClNO3

分子量：323.8228

化学名称N-tert-Butyl-4-[5'-ethoxy-4-[2-(4-morpholinyl)ethoxy]-2'-oxospiro

[cyclohexane-1,3'-indolin]-1'-ylsulfonyl]-3-methoxybenzamide fumarate

The reduction of diethyl 3-(methoxymethoxy)glutarate (I) with LiAlH4 in THF gives

3-(methoxymethoxy)pentane-1,5-diol (II), which is treated with Ts-OH and TEA in

THF to yield the disulfonate (III). The condensation of (III) with 5-

ethoxyindolin-2-one (IV) by means of tBu-OK in THF affords the spiro compound (V),

which is deprotected with HCl in methanol to afford the spiranic alcohol (VI). The

oxidation of (VI) with pyridinium chlorochromate (PCC) over Al2O3 provides the

spiranic cyclohexanone (VII), which is treated with 2-chloroethanol (VIII) and

Ms-OH in toluene to give the ketal (IX). The reaction of (IX) with zinc

borohydride and trimethylsilyl chloride in ethyl ether/dichloromethane yields the

2-chloroethoxy derivative (X), which is condensed with 4-(N-tert-butylcarbamoyl)-

2-methoxybenzenesulfonyl chloride (XI) by means of tBu-OK in THF to afford the

adduct (XII). Finally, the target compound is obtained by condensation of (XII)

with morpholine (XIII) by means of NaI in DMF, followed by treatment with fumaric

acid.

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